December 29, 2003
Should Be Stopped at Breast Cancer Diagnosis
Newswire) -- Many women take hormone replacement therapy to prevent
the symptoms of menopause. But if a woman on HRT is diagnosed
with breast cancer, should she be taken off the hormones? New
research shows HRT should be stopped at the time of a breast cancer
Researchers from the
United Kingdom looked at the short-term biologic response after
a woman is taken off HRT. The study included 140 women who had
been using HRT at the time breast cancer diagnosis. The breast
tumors were removed between two days and 31 days later. Of the
women, 125 women stopped HRT at the time of biopsy and 15 continued
to receive HRT until surgery. In addition, 55 women with breast
cancer from the same period who were not receiving HRT at diagnosis
were included in the study. Researchers then looked at the changes
in the cells in each patient.
The study shows women
who stopped HRT had a significant decrease in the measure of the
epithelial cell proliferation. The changes were seen in the estrogen
receptor positive tumors. They also found changes in other cells
that were not observed in the other group of patients.
estrogen receptor positive breast cancer has a favorable biological
response to withdrawal of HRT. Therefore, study authors say HRT
should no longer be given to women who have been diagnosed with
breast cancer. They add the use of HRT by women with estrogen
receptor positive tumors should proceed with extreme caution.
article was reported by Ivanhoe.com, who offers Medical Alerts
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